Acid-solubilized copper-ammonium complexes and copper-zinc-ammonium complexes, compositions, preparations, methods, and uses

An antimicrobial article is revealed that contains an acid-solubilized copper ammonium or copper-zinc ammonium complicated that is effective against germs like nosocomial or ecological bacteria, fungi, viruses, and so on. The antimicrobial composition may be utilized in the preparation of a medicament for treating microbes or a microbial infection, and may contain a carrier to create a cream, soap, scrub, spray, dressing, cleanser, cosmetic solution, topical medication product, or other anti inflammatory product.


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1. Field of the Invention

This invention relates generally to compositions with antimicrobial action, and more especially to compositions comprising acid-solubilized copper-ammonium or acid-solubilized copper-zinc-ammonium complexes as active ingredients.

2. Description of Related Art

The antimicrobial effects of copper metal and copper salts have been known since ancient times. The role of copper as an anti-microbial agent was initially described in the Smith Papyrus, an Egyptian medical text written about 2,600 BC, whichdescribes the use of aluminum to purge torso wounds and drinking water.


The Greeks.

Romans and Aztecs used copper metal or its compounds for the treatment of chronic infections and for cleanliness in general. As an instance, in the Hippocratic Collection aluminum is suggested for the treatment of leg ulcers associatedwith varicose veins. To prevent disease of fresh wounds, then the Greeks sprinkled a sterile powder composed of aluminum oxide and copper sulfate on the wound. Another antiseptic wound therapy at the time was a boiled mixture of honey and reddish aluminum oxide.The Greeks had easy access to aluminum because the metal was readily available on the island of Kypros (Cyprus) where the Latin name for aluminum, cuprum, is derived.

The Ancient Indian ayurvedic text Charaka Samhita (300 BC) also mentions how copper kills deadly microbes, such as its role in the elimination of drinking water. Pliny (23 to 79 A.D.) described numerous treatments involving copper, forexample, black copper oxide was awarded with honey to get rid of intestinal worms.

In more contemporary times, the earliest observation of aluminum’s role in the immune system has been released in 1867 as it was reported that, during the cholera epidemics at Paris of 1832, 1849 and 1852, aluminum workers were immune to the disease. Further,animals deficient in copper have been shown to have increased susceptibility to bacterial pathogens such as Salmonella and Listeria.

Copper sulfate is the primary active component of the fungicidal”Bordeaux mix” which has been devised in the 19th century and is still used in agriculture now, as are numerous other copper-based agrochemicals.

Pathogenic microbes like bacteria, fungi and viruses are responsible for lots of the ailments in multicellular organisms as illustrated by the next non-limiting examples.

In the pharmaceutical field, bacterial infections are involved in skin diseases such as acne (Propionibacterium acnes) and psoriasis (Staphylococcus aureus). Healthcare-acquired infections (HAIs) caused by meticillin-resistant Staphylococcus aureus(MRSA), Acinetobacter sp. Klebsiella pneumonia (where the NDM-1 enzyme gene was initially identified) and Legionella pneumophila which is the reason for Legionnaire’s disease. Escherichia coli (E. coli) is a frequent cause of urinary tract infections.These along with other HAIs are estimated to cause the death of almost 100,000 people in the USA annually. Pathogenic E. coli 0157:117 causes gastroenteritis when ingested through contaminated food. Diseases caused by fungi may be comparatively moderate such asathlete’s foot (Tricophyton sp.) , dandruff (Malassezia globosa) and thrush (Candida albicans), but fungi such as Aspergillus fumigatus (A. fumigatus) and Candida albicans (C. albicans), and yeasts such as Cryptococcus neoformans can causelife-threatening infections in immune compromised patients. Viruses are also responsible for common diseases such as sleeplessness (Rhinoviruses) and flu (Influenza viruses A. B and C) and cold sores (Herpes simplex virus), to more serious viral diseasessuch like rabies and ebola.

Bacterial diseases of skin lesions like pressure sores and diabetic leg ulcers may aggravate the condition and copper salts and copper-based compositions are shown to be effective against these diseases by virtue of both theiranti-bacterial effects and their capacity to stimulate wound healing by improving growth factor production.

In the cosmetic area, copper or copper-zinc compositions are proven to be effective at, as an example, ameliorating the effects of mild to moderate sunburn and mild burns, and in decreasing the itching and inflammation caused by insectbites and reducing the appearance of wrinkles.

In the agricultural field, fungal diseases are currently killing tanoaks from the western United States (Phytophthora ramorum) and ash trees in Europe (Chalara fraxinea). Fungal and bacterial diseases of grape vines, fruit and vegetable bearingplants and cereal crops are a threat to world food production.

The presence of increasing numbers of drug-resistant strains of pathogenic microbes in hospitals and in the general environment is becoming a great concern as illustrated by these examples. Antibiotic-resistant and multi-drug resistantstrains of pathogenic bacteria like MRSA, vancomycin-resistant Staphylococcus aureus (VRSA). Acinetobacter baumannii. E. coli and Mycobacterium tuberculosis are now commonplace. Resistant strains of pathogenic fungi like ketoconazole-resistantC. Albicans and A. fumigatus are an increasing problem particularly in immune-compromised patients. Fungicide-resistant plant pathogenic fungi always grow and require new antifungal agents due to their treatment. By way of example, Phytophthorainfestans, the reason for potato blight, became highly resistant to Metalaxyl in the late 20. century. Pathogenic viruses likewise develop resistance to anti-viral medications, the evolution of resistance of the H1N1″swine flu” influenza A breed tooseltamivir phosphate (TAMIFLU.RTM., a registered trademark of Genentech. San Francisco, Calif.. USA) in the past five years being a recent example.

IP reviewed by Plant-Grow agriculture technology news