A means for antimicrobial treatment comprising applying to microbes a composition comprising a diluting solvent (e.g., water), an antimicrobially-active solvent having a density different from the density of the diluting solvent, and an optional cosolvent, surfactant, or other antimicrobial agent, wherein the amount of antimicrobially-active solvent or other antimicrobial agent is high and the amount of cosolvent or surfactant is sufficiently low so the composition provides higher than a 1-log purchase decline in the population of bacteria or spores of Bacillus cereus in just 10 seconds at 60. degree. C. Preferred methods of the invention employ compositions comprising an extra antimicrobial agent like peroxyacetic acid. Compositions for use in the method can be ready as targets, and used full strength or in diluted form.
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There’s been a longstanding need for antimicrobial agents having improved antimicrobial efficacy and improved speed of action. The specific requirements for such representatives vary in line with the intended application (e.g., sanitizer,disinfectant, sterilant, aseptic packing therapy, etc.) and the applicable public health requirements. By way of example, as set out in Germicidal and Detergent Sanitizing Action of Disinfectants, Official Methods of Analysis of the Association ofOfficial Analytical Chemists, paragraph 960.09 and applicable sections, 15th Edition, 1990 (EPA Guideline 91-2), a sanitizer should provide a 99.999% reduction (5-log order decrease ) within 30 minutes at room temperature, 25. +-.2. degree. C., againstseveral test organisms.
Many anti inflammatory agents (e.g., iodophors, peracids, hypochlorites, chlorine dioxide, ozone, etc.) possess a broad spectrum of antimicrobial properties. However, these agents sometimes have inadequate action against bacterial spores, fungalspores, and parasites. Killing, inactivating, or otherwise reducing the active population of bacterial parasites and spores on surfaces is particularly hard. Bacterial spores have a unique chemical makeup of spore layers which make them more resistantthan vegetative bacteria into the antimicrobial effects of physical and chemical agents. Likewise, the exceptional chemical composition of fungal cells, especially mould spores, makes them more resistant to physical and chemical agents than are othermicroorganisms. This immunity can be particularly troublesome when the parasites or spores are located on surfaces like meals, food contact sites, ware, hospitals and veterinary centers, surgical implements, and hospital and surgical linens andgarments.
Control of this mould Chaetomium funicola, and of bacterial spore-forming microorganisms of the Bacillus species, can be especially significant during food packaging, especially during cold or cold aseptic filling of food and beverage products.Microorganisms of the Bacillus species comprise Bacillus cereus, Bacillus mycoides, Bacillus subtilis, Bacillus anthracis, and Bacillus thuringiensis. These latter microorganisms share many phenotypical properties, have a high level of chromosomalsequence similarity, and are known enterotoxin makers. Bacillus cereus is one of the most problematic because Bacillus cereus has been identified as owning increased immunity to germicidal chemicals used to decontaminate ecological surroundings. By way of instance, Blakistone et al., Efficacy of Oxonia Active Against Selected Sporeformers, Journal of Food Protection, Volume 62, pp.262 267, reported that Bacillus cereus was more tolerant to the effects of conventionally formulated peroxyacetic acidgermicides than all other spore-forming bacteria tested, including other Bacillus and Clostridium species.
Bacillus cereus is frequently diagnosed as a cause of gastrointestinal disorders and has been indicated to be the cause of several food-borne disease outbreaks. Owing to its rapid sporulating capacity, Bacillus cereus easily survives in theenvironment. Bacillus cereus is omnipresent in nature, and therefore can normally be found in animal feed and fodder. Bacillus cereus can contaminate raw milk through feces and soil, and can endure intestinal passage in cattle and the pasteurizationprocess.
Bacillus cereus is also known to cause serious human illness via environmental contamination. By way of instance, Bacillus cereus is known to cause post-traumatic injury eye infections, which could result in visual impairment or loss of vision within 1248 hours following infection. Additionally, Bacillus cereus is seen as transferable from washed surgical garments to patients.
Agents having greater or faster activity against bacterial spores, fungi, and other immune microorganisms (especially germs of the Bacillus species) could help meet a significant public health requirement, and one which isn’t adequatelyaddressed by present commonly-used antifungal agents.
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