Catheter receptacle provided with an antimicrobial compound
A catheter assembly (110, 210) containing a catheter (130, 230) and also a receptacle (120, 220) is disclosed. The receptacle is arranged to accommodate at least part of said catheter and having at least one opening (123) for withdrawal of said catheter. Further, the receptacle is provided with an antimicrobial compound (301) at least in the neighborhood of the opening and at least on the outer surface of the receptacle, stated antimicrobial compound preventing germs from being transferred to stated catheter while being pulled through said a minumum of one opening.
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Catheters find their usage in many different medical programs, such as urinary catheters for bladder drainage.
These urinary catheters are employed in a number of populations, including the elderly, stroke victims, spinal cord-injured patients, post-operative patients and those with obstructive uropathy. Despite adherence to sterile guidelines for theinsertion and upkeep of urinary catheters, catheter-associated infections continues to pose a significant problem. When medical devices such as a catheter is introduced into the human cavity, the normal human defense barrier may be penetrated, which canresult in debut of germs, fungi, vira, or tissue-like or multiple coordinated cells. Urinary tract infection (UTI), for instance, is a problem associated with the use of urinary catheters, such as hydrophilic catheters with hydrophiliccoatings for intermittent use. It’s estimated that nearly one-quarter of esophageal cord-injured patients develop symptomatic UTI throughout their hospital program. Gram-negative bacilli accounts for nearly 60-70%, enterococci for about 25 percent andCandida species for about 10% of cases of UTI. It’s well known that persons practicing intermittent urethral catheterization as a daily routine frequently have issues with symptomatic UTI.
To be able to maintain the catheter in a clean and preferably sterile state, each catheter is normally pre-packed at a receptacle from the manufacturer.
Furthermore, so as to ease the usage and also to increase operation of the catheter, the assemblies have in recent years developed to include a rupturable wetting liquid pouch or container as well, in which wetting of the catheter may beperformed without using externally supplied water, and without breaking the sealed state of it until planned usage of the catheter. Such assemblies are revealed in for example WO 97/26937, WO 01/43807 and WO 98/11932. Further, therefore called”ready-to-use” catheters are suggested, in which the catheter is arranged in the receptacle together using a wetting fluid in such a manner that the catheter is kept in a wetted, triggered condition by said fluid. Such ready-to-use catheterassemblies are revealed in for example WO 00/47494 and WO 98/19729.
Further, in order to maintain sterility and cleanness of the catheter, the catheter could be coated with an antimicrobial chemical for prevention of fungal infection. US 2006/0240069, for instance, discloses a use of a minumum of one salt oforganic acid(s), and preferably a benzoate or a sorbate, as an antimicrobial agent. The chemical described can also be incorporated in a wetting fluid, usable for providing low-friction surface of a hydrophilic coating of a catheter bytreatment with the wetting fluid, thus making the hydrophilic coating antimicrobial when triggered by the wetting liquid. Further, WO 00/09173 discloses a stabilized composition having antibacterial, antiviral or anti-fungal action characterized inthat it comprises a silver substance. Light stabilized silver composition can be introduced into catheters or similar medical devices.
But, though antimicrobial coating as well as the maintenance of the catheter in a sterile condition serve to inhibit bacterial growth and prevent bacterial infections, insertion of the catheter into the urethra proceeds to constitute arisk for introduction of bacteria to the human body. One of the causes of this is that bacteria may still be moved into the catheter during withdrawal of the catheter from its receptacle. Particularly, the withdrawal in the receptacle pose aproblem when the outer surface of the receptacle is prone to develop into contact with the catheter as the catheter is withdrawn, thus allowing germs in the receptacle to come into contact with the catheter.
Thus, there is still a demand for improved means of preventing bacterial infections and related diseases related to growth and transfer of microbes in the use of catheters.
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