Chitosan hydrogel derivatives as a coating agent with broad spectrum of antimicrobial activities
The current invention relates to water soluble quaternized chitosan derivatives which form hydrogel matrix using wide antimicrobial properties for the coating and protection of medical device. Hydrogel is attractive as an antimicrobial coating because its hydrophilicity intrinsically prevents the reversible nonspecific attachment of germs. In order to achieve hydrogel formation, quaternized chitosan could be grafted with polymerizable groups, particularly photocrosslinkable groups, like methacrylates, PEG derivatives and be transformed to hydrogels via a thermal or UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems which contain water at an equilibrium state forming cushion water shield. The current invention is widely used in many medical devices. This invention describes the creation of novel hydrogels based on quaternized ammonium chitosan derivatives which has been grafted with photocrosslinkable groups, hence supplying hydrogels as antimicrobial shield coat representative.
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Chitosan is a .beta.
-1,4-linked polymer of glucosamine (2-amino-2-deoxy-.beta. -D-glucose) and lower amounts of N-acetylglucosamine. It is formed by the deacetylation of chitin (poly-N-acetylglucosamine), an abundant byproduct of the crab andshrimp processing industries.
The water solubility and antimicrobial property of indigenous chitosan can be achieved or improved via the quaternization of chitosan. Quaternized chitosan, as a result of the quaternization of the amino group at the C-2 place, gained apermanent positive control on the polysaccharide backbone. Quaternized chitosans find utility in cosmetic preparations, food preservation and packaging, coating substances, disinfectants and biomedical applications (JP-A-2005-290297, JP-A-8-144121,JP-A-2004-515813).
Therefore, quaternized chitosan can be used to get hydrogel formation and devised as anti aging contact lens coating. To be able to achieve hydrogel formation, quaternized chitosan can be grafted with photocrosslinkable groups, such as(meth)acrylates, and also be transformed to hydrogels via a UV polymerization process. Hydrogels are hydrated cross-linked polymeric systems which contain water in an equilibrium condition and have been extensively used in many biomedical applications includingcontact lenses, bio-implants such as urinary catheters, pacemaker, heart valves, artificial heart, mammary prosthesis, intraocular lenses, wound dressings, artificial organs and delivery carriers to the bioactive reagents because of their high level ofbiocompatibility. However, there haven’t been any studies on using quaternized chitosan hydrogels as antimicrobial medical device coating. The current invention describes the creation of novel hydrogels based on quaternized chitosan that has beengrafted with polymerizable group, especially photocrosslinkable group, and relates to medical apparatus having resultant antimicrobial activities.
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