Lavage and/or infusion using CSA compounds for increasing fertility in a mammal

Increasing fertility in a mammal uses cationic steroidal antimicrobial (CSA) compounds and CSA-containing compositions. Such therapy in a mammal includes administering a formula (e.g., lavage and/or infusion) containing at least one CSA compound, or pharmaceutically acceptable salt thereof, into the reproductive structure(s) of this mammal (e.g., horse, dairy cow, individual, etc.). The formula can be applied topically as lavage and/or extract to desirable reproductive structures, like the vagina, uterus, uterus, manhood, or combinations thereof. The formula may kill both planktonic and biofilm forms of semen killing germs, and can at least partly split a microbial plaque or movie found within any of the reproductive structures (e.g.( the uterus). Even the CSA or pharmaceutically acceptable salt thereof can be selective or preferential in its action, so as to preferentially kill sperm killing germs without causing injury to beneficial microbes too living within the reproductive structure of the mammal.

 

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BACKGROUND

 

 
1. The Field of the Invention
 

 
The present invention relates to compositions and methods for raising fertility within a mammal with cationic steroidal antimicrobial (CSA) compounds.
 

 
2. The Relevant Technology
 

 
Maintaining fertility in dairy cows, horses, domestic animals, and other mammals has been of importance to people engaged in the farming sector. Loss of fertility significantly lessens the value of breeding animals, which may only then beused for meat but that might not be suitable for such use. Thus, fertility reduction, especially premature infertility, can substantially or completely destroy the economic worth of a creature relied upon for reproduction.
 

 
In general, there might be a number of motives to restore or enhance fertility in a wide array of different mammals, including people. Current treatments to boost fertility comprise administration of fertility drugs, such as hormones or othersubstances that act by accelerating ovulation, and/or surgical procedures, some of which can be quite invasive and expensive.
 

 
In addition to older age, infertility may also be caused by bacterial or fungal endometritis, which occurs if a bacteria or fungus (e.g., yeast) contaminates the uterus and causes infection and inflammation. In some cases, endometritis can besexually transmitted, such as Contagious Equine Metritis (CEM), caused by Taylorella equigenitalis, a Gram negative coccobacillus. The bacteria can survive for an protracted period on the external genitalia of the stallion and the clitoris or vagina ofthe mare. When infected, the stallion may show no clinical signs. The mare, however, typically presents acute endometritis with a thick, grey, mucoid discharge after breeding and may brief cycle due to inflammation. The severe signs may subsiderapidly, together with a few mares staying as asymptomatic carriers.
 

 
Endometritis is hard to treat and has a higher rate of recurrence. Present-day treatments could include uterine lavage with substantial volumes of fluid and/or administration of dimethylsulfoxide (DMSO), antifungal agents (e.g., clotrimazole,amphotericin, fluconazole, nystatin), or antibiotics. Such therapies are expensive and results uncertain. The prognosis is often poor since therapy only affects certain phases of fungal or bacterial development. In some cases, the microbe may beattached within folds of the endometrium, or even the mare could have delayed uterine clearance. Despite effective treatment, chance of re-infection is large.
 

 
Accordingly, there remains a present but blessed need to locate reliable remedies for increasing fertility in mammals.
 

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