Metabolic regulators

The present invention provides metabolic regulators, which are proteins (like fusion proteins, polyunsaturated fats or full-length proteins) that bind to certain metabolites and that may be used to control the access to this metabolites in cells, especially plant cells. Proteins of the invention comprise one or more metabolic regulator proteins, may be truncated or full length, can further include a transmembrane domain name or lipoylation site or can further include a transit peptide. Metabolic regulators of this creation can be soluble, e.g., cytosolic soluble, may be anchored into a biological membrane or may be organelle targeted or apoplastic targeted. The present invention also provides nucleic acid molecules encoding the metabolic regulators, methods of producing the nucleic acid molecules, methods for producing transformed organisms, such as plants, photosynthetic organisms, microbes, invertebrates, and vertebrates, and techniques for controlling availability of metabolites into a host cell.

 

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BACKGROUND

 

 
The present invention provides metabolic regulators, which are proteins (such as fusion proteins, polyunsaturated fats or saturated proteins) that bind to certain metabolites and that may be used to control the availability of these metabolitesin cells, particularly plant cells. The proteins of the invention include one or more metabolic regulator proteins, for example bacterial periplasmic binding proteins (bPBPs) or domain names from prokaryotic and eukaryotic proteins which are functionally similarto that the bPBPs. The present invention also provides nucleic acid molecules encoding the metabolic regulators, methods of making the nucleic acid molecules, and means of making altered organisms, such as plants, photosynthetic organisms, microbes,invertebrates, and vertebrates.
 

 
The books and other materials used herein to illuminate the background of the invention, and in particular, cases to provide additional details regarding the clinic, are incorporated by reference in their entirety for all that theydisclose, and for convenience are referenced at the subsequent text with reference number and are listed by reference number from the appended bibliography.
 

 
Plants want resources in the form of elements like carbon, nitrogen, sulfur, phosphate, hydrogen, oxygen and minerals, for normal growth and development. The sources could be absorbed in the air and soil in the kind of carbon dioxide,ammonium, nitrate, phosphates, water, oxygen and ions. Some sources have to be assimilated and therefore are synthesized into more complex molecules like sugars, lipids, amino acids, nucleotides and many different secondary molecules that are essential for plantgrowth, development, and reproduction. Many of the molecules, like nitrogen and carbon, form the building blocks for biological polymers, like polypeptides, DNA, RNA, starch, and cellulose, which modulate and sustain life. What’s more, waterup-take and usage can also be connected to the utilization of the above-mentioned chemicals.
 

 
Plants must organize the up-take, assimilation, distribution, allocation and mobilization of resources in the shape of carbon, nitrogen, sulfur, phosphate and ions to maximize growth and development, and to preserve health and their ability ofreproduce through seed and fruit production. To coordinate these processes crops have developed complicated monitoring and signaling networks that incorporate the up-take, synthesis, distribution, and allocation of assets available to the plant (31, 32,33, 38, 58, 89, 94, 95, 152, 154, 165, 166, 171). Recent findings indicate that plants monitor these processes through a group of receptors called plant glutamate receptors that pertain to metabolites, especially amino acids (31, 38, 49, 60, 99, 154).
 

 
There is a need in the art for compositions and ways of controlling the availability of metabolites in cells, especially plant cells.
 

IP reviewed by Plant-Grow agriculture technology news