Metabolic regulators

The present invention provides metabolic regulators, which are proteins (like fusion proteins, truncated proteins or full-length proteins) that bind to certain metabolites and that may be utilised to control the availability of the metabolites in cells, especially plant cells. Proteins of the invention include one or more metabolic regulator proteins, which may be truncated or full length, may further comprise a transmembrane domain name or lipoylation site or can further comprise a transit peptide. Metabolic regulators of the creation can be soluble, e.g., cytosolic soluble, can be anchored into a biological membrane or may be organelle concentrated or apoplastic targeted. The present invention also provides nucleic acid molecules encoding the metabolic processes, methods of making the nucleic acid molecules, methods for making transformed organisms, such as plants, photosynthetic organisms, microbes, invertebrates, and vertebrates, and methods for controlling accessibility of metabolites into a host cell.


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The current invention offers metabolic regulators, which are proteins (such as fusion proteins, polyunsaturated fats or saturated proteins) that bind to specific metabolites and which may be used to control the access to the metabolitesin cells, particularly plant cells. The proteins of the invention include one or more metabolic regulator proteins, for example bacterial periplasmic binding proteins (bPBPs) or domain names in prokaryotic and eukaryotic proteins which are functionally similarto that the bPBPs. The present invention also provides nucleic acid molecules encoding the metabolic regulators, methods of creating the nucleic acid molecules, and methods for making transformed organisms, including plants, photosynthetic organisms, microbes,invertebrates, and vertebrates.

The publications and other materials used herein to illuminate the background of this creation, and specifically, cases to present additional details respecting the practice, are incorporated by reference in their entirety to all that theydisclose, and for convenience are referenced at the subsequent text by reference amount and are listed by reference number in the appended bibliography.

Plants want resources in the shape of components such as carbon, sulfur, phosphorus, phosphate, oxygen, oxygen and minerals, such as normal growth and development. The resources can be absorbed by the soil and air in the kind of carbon dioxide,ammonium, nitrate, phosphates, oxygen, water and ions. Some resources have to be assimilated and are synthesized into more complex molecules such as sugars, lipids, amino acids, nucleotides and a variety of secondary molecules that are necessary for plantgrowth, development, and reproduction. Many of the molecules, such as carbon and nitrogen, form the building blocks for biological polymers, such as polypeptides, DNA, RNA, starch, and cellulose, that regulate and preserve life. What’s more, waterup-take and usage can also be connected to the utilization of the above-mentioned compounds.

Plants must coordinate the up-take, assimilation, supply, allocation and mobilization of resources in the form of carbon, nitrogen, sulfur, phosphate and ions to optimize growth and development, and to maintain health and their ability ofreproduce through seed and fruit production. To coordinate these processes plants have developed sophisticated monitoring and signaling networks which incorporate the up-take, synthesis, distribution, and allocation of resources available to the plant (31, 32,33, 38, 58, 89, 94, 95, 152, 154, 165, 166, 171). Recent findings suggest that plants monitor these processes through a group of receptors known as plant glutamate receptors which bind to metabolites, specifically amino acids (31, 38, 49, 60, 99, 154).

There’s a need in the art of compositions and ways of controlling the availability of metabolites in cells, particularly plant cells.

IP reviewed by Plant-Grow agriculture technology news