Nanoparticle compositions and methods for treating onychomychosis

A nanoparticle composition for treating onychomycosis consists of spherical-shaped nanoparticles using a particle size and a particle size distribution and coral-shaped nanoparticles using a particle size and a particle size distribution combined inside a penetrating solvent configured to supply the nanoparticles to target region of a nail or surrounding tissue. The nanoparticle article can be combined with a provider to augment or provide application of the nanoparticle composition into a goal area. The mucous membranes can deliver the nanoparticles into an infected area inside the nail or at the bed of the nail so as to kill or deactivate the fungal microbes resulting from the onychomycosis.

 

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BACKGROUND

 

 
1. Field of the Invention
 

 
Disclosed herein are nanoparticle compositions and methods for treating onychomycosis, such as stabilized multi-component anti-fungal nanoparticle compositions for treating onychomycosis and methods for making and using these compositions.
 

 
2. Relevant Technology
 

 
Onychomycosis is a fungal disease of the fingernail or toenail. These infections can range from mild but irritating to debilitating and inflamed. For many, like those that are immunocompromised (e.g., because of medication, AIDS, diabetes, cancer,leukemia, or cancer treatment), an untreated infection can lead to a severe and even life threatening condition. Furthermore, such infections can negatively affect one’s desirable appearance and can lead to cosmetic concerns, with infected nailsbecoming brittle, brittle, and stained, together with the potential for permanent damage to the infected nails. Further, some who’ve onychomycosis may also suffer from related skin lesions, lesions, or other dermal irritations as a result of an allergicreaction to the fungus inherent the onychomycosis.
 

 
Treatment of onychomycosis is typically carried out by eliminating the inherent parasitic cause of the problem. Fungi which are typically associated with onychomycosis include dermatophytes, yeasts like Candida albicans, andnondermatophytic molds. But, antifungal therapy can be hard, because of the fact that fungi are eukaryotic organisms which don’t respond to antibiotics, limiting the number of compounds useful against the underlying fungi. Additionally, theinfection is typically embedded deep within the nail, which makes it hard to give contact of the treatment chemical to the disease. Additionally, because nail growth is relatively slow, it might take a protracted time period (e.g., to a year or even more insome instances ) for older, infected parts of the nail to proceed to a location where treatment is more achievable. For remedies that must typically be implemented daily, if not more frequently, compliance over such an elongated period of time becomes extremelydifficult. In some cases, removal of all or portion of the nail might be recommended or required, which may be painful to the patient.
 

 
Accordingly, there has been and remains a necessity to discover reliable treatments for use in treating onychomycosis. Such treatments should be in a position to kill or deactivate the underlying bacterial infection causing the disease without causingunnecessary pain or undue harm to the organism being treated (e.g., animal or human ).
 

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