Substituted oxazolidines as anti-bacterial agents

The present disclosure relates to compounds of Formula I, its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms thereof and pharmaceutical compositions comprising them as the active ingredient which can be used as medicaments. The aforementioned substances can also be utilised in the production of medicaments for treatment, prevention or suppression of diseases, and conditions mediated by microbes. The present disclosure also is related to the synthesis and characterization of aforementioned substances. ##STR00001##

 

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BACKGROUND

 

 
There’s an alarming global concern regarding the rapid growth of antibiotic resistance, which might lead to strains against that there are no successful antibacterial agents. Generally, bacterial pathogens may be categorized as eitherGram-positive or even Gram-negative pathogens. Antibiotic compounds with powerful activity against both Gram-positive and Gram-negative pathogens are regarded as having a wide spectrum of activity. Current antibacterial drugs used to treat and preventbacterial disease have been found to have limited impact. Further, there is a continuing requirement to identify new substances with potent antibacterial activity with decreased possibility of developing immunity, which possess improved efficacy againstbacterial infections that resist treatment with currently available antibiotics, or that possess selectivity against target bacteria.
 

 
In the foregoing, it is clear that compounds used in the state of the art to treat and prevent bacterial infection have been found to have limited influence. Further, there is a continuing requirement to identify new compounds with improvedantibacterial action, which have significantly less potential for developing immunity, which have improved efficacy against bacterial infections that resist treatment with currently available antibiotics, or which have unexpected selectivity againsttarget microorganisms.
 

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